童愛軍

女， 清華大學(xué)化學(xué)系， 教授/研究員/教授級高工或同等級別

學(xué)習(xí)/工作經(jīng)歷

(1) 1979.9–1983.7, 新疆大學(xué)化學(xué)系, 學(xué)士
(2) 1983.8-1985.3, 新疆大學(xué)化學(xué)系, 助教
(3) 1985.3-1986.1, 東北師范大學(xué)留日預(yù)備校, 日語學(xué)習(xí)
(4) 1986.7-1987.3, 日本明星大學(xué)化學(xué)系, 公派留學(xué)生
(5) 1987.4–1992.3, 日本明星大學(xué)化學(xué)系, 博士, 導(dǎo)師: TANAKA Shigeyuki 田中誠之
(6) 1992.4至今，清華大學(xué)化學(xué)系，講師、副教授、教授

研究領(lǐng)域和興趣

分析化學(xué)，熒光探針

主要業(yè)績

長期從事與生命分析相關(guān)的發(fā)光分析理論及應(yīng)用研究工作，是國內(nèi)較早并持續(xù)進(jìn)行該領(lǐng)域的研究者之一。近年主要從事發(fā)光性功能試劑的合成與生物分子的分子識別分析，在熒光傳感器及功能發(fā)光材料的研究領(lǐng)域進(jìn)行了深入系統(tǒng)的研究。相關(guān)研究成果包括: (1) 設(shè)計合成了多種新型且具有良好分析應(yīng)用前景的聚集誘導(dǎo)熒光及刺激響應(yīng)熒光分子，用于環(huán)境、生命相關(guān)重要分析物的高靈敏度、高選擇性檢測、活細(xì)胞熒光成像以及防偽、紫外光強(qiáng)測量等方面，相關(guān)工作在J. Am. Chem. Soc. 2014; Anal. Chem. 2017; Chem.Comm. 2017; Chem.-Eur. J. 2019, 2016; J. Org. Chem. 2009; J. Phys. Chem. C 2011, 2013, 2017; ACS Appl. Mater. Interfaces 2016; J. Mater. Chem. 2011 等期刊上發(fā)表。其中，基于水楊醛席夫堿的聚集誘導(dǎo)發(fā)光分子由本課題組于2009 年首次報道，基于其易于化學(xué)修飾、合成簡單、發(fā)光機(jī)理明確，Stokes 位移大的獨特優(yōu)點，已被國內(nèi)外多個課題組進(jìn)行了深入研究，也已用于活細(xì)胞成像。(2)建立了非標(biāo)記的功能脫氧核糖核酸傳感系統(tǒng)，實現(xiàn)了非熒光標(biāo)記法檢測重金屬和有機(jī)小分子代謝物（J. Am. Chem. Soc., 2009; Anal. Chem. 2012；Anal. Chem. 2014；Chem. Commun.2015）。(3) 設(shè)計合成了多種絡(luò)合型或反應(yīng)型金屬離子熒光傳感器、pH 熒光傳感器、酶熒光傳感器等，建立了高選擇性高靈敏度金屬離子的熒光增強(qiáng)型、比率型檢測方法和細(xì)胞成像方法，相關(guān)工作在Org. Lett. 2006；Chem.Comm. 2010；J. Mater. Chem. 2011；J. Phys. Chem. B 2015, 2018 等期刊上發(fā)表。

代表成果

1. Lu Peng; Ruirui Wei; Yifei Guo; Xiaokun Zheng; Yue Zheng; Yiwen Ding; Yu Xiang; Aijun Tong, Tuning Emission Wavelength of Polymorphous Crystal via Controllable Alkyl Chain Stacking and Its Vapor- and Thermo-Responsive Fluorescence, Chem. Eur. J., 2019, 25: 8043~8052
2. Lu Peng; Lu Xiao; Yiwen Ding; Yu Xiang; Aijun Tong, A simple design of fluorescent probes for indirect detection of b-lactamase based on AIE and ESIPT processes, J. Mater. Chem. B, 2018, 6: 3922~3926
3. Lu Peng; Shidang Xu; Xiaokun Zheng; Xiamin Cheng; Ruoyu Zhang; Jie Liu; Bin Liu; Aijun Tong, Rational design of a red-emissive fluorophore with AIE and ESIPT characteristics and its application in light-up sensing of esterase, Anal. Chem., 2017, 89: 3162~3168
4. Yue Zheng; Xiaokun Zheng; Lu Peng; Yu Xiang; Aijun Tong, Photoactivatable aggregation-induced emission of triphenylmethanol, Chem. Comm., 2017, 53:11130~11133
5. Xiaokun Zheng; Yue Zheng; Lu Peng; Yu Xiang; Aijun Tong, Mechanoresponsive fluorescence of 2-aminobenzophenone derivatives based on amorphous phase to crystalline transformation with high “off?on” contrast ratio, J. Phys. Chem. C, 2017, 127: 21610~21615
6. Kai Li; Yu Xiang; XiaoyanWang; Ji Li; Rongrong Hu; Aijun Tong; Ben Zhong Tang, Reversible photochromic system based on rhodamine B salicylaldehyde hydrazone metal complex, J. Am. Chem. Soc., 2014, 136: 1643~1649
7. Panshu Song; Xiaotong Chen; Yu Xiang; Lei Huang; Zhaojuan Zhou; Ruirui Wei; Aijun Tong, A ratiometric fluorescent pH probe based on aggregation-induced emission enhancement and its application in live-cell imaging, J. Mater. Chem., 2011, 21: 13470~13475
8. Weixin Tang; Yu Xiang; Aijun Tong, Salicylaldehyde azines as fluorophores of aggregation-induced emission enhancement characteristics, J. Org. Chem., 2009, 74: 2163~2166
9. Yu Xiang; Aijun Tong; Yi Lu, Abasic site-containing DNAzyme and aptamer for label-free fluorescent detection of Pb2+ and adenosine with high sensitivity, selectivity, and tunable dynamic range, J. Am. Chem. Soc., 2009, 131: 15352~15357
10. Yu Xiang; Aijun Tong, A New Rhodamine-Based Chemosensor Exhibiting Selective FeIII-Amplified Fluorescence, Org. Lett., 2006, 8, 1549-1552

*以上信息由高級會員個人更新和維護(hù)。