劉莊

男， 蘇州大學(xué)功能納米與軟物質(zhì)研究院， 教授/研究員/教授級高工或同等級別

學(xué)習(xí)/工作經(jīng)歷

2000.09-2004.07，北京大學(xué)，化學(xué)與分子工程學(xué)院，本科生
2004.09-2008.12，斯坦福大學(xué)，化學(xué)系，博士生
2008.12-2009.06，斯坦福大學(xué)，化學(xué)系，博士后
2009.06 - 至今，蘇州大學(xué)，功能納米與軟物質(zhì)研究院，教授，執(zhí)行院長（2016年起）

研究領(lǐng)域和興趣

生物材料、化學(xué)生物學(xué)、納米化學(xué)

主要業(yè)績

劉莊教授團(tuán)隊(duì)專注于生物材料、化學(xué)生物學(xué)、納米醫(yī)學(xué)領(lǐng)域的交叉學(xué)科研究，當(dāng)前主要研究興趣包括基于生物材料、化學(xué)生物學(xué)和合成生物學(xué)工具實(shí)現(xiàn)免疫微環(huán)境調(diào)控與腫瘤免疫治療，以及基于新型納米載體的跨生物屏障藥物遞送技術(shù)。共發(fā)表學(xué)術(shù)論文400余篇，論文總引用超過9萬次，H因子165。獲國家杰出青年基金資助；入選中組部萬人計(jì)劃“領(lǐng)軍人才”、教育部“長江學(xué)者特聘教授”、英國皇家化學(xué)會會士 (RSC Fellow)、美國醫(yī)學(xué)與生物工程學(xué)院會士 (AIMBE Fellow)；獲科學(xué)探索獎、中國青年科技獎、江蘇省科學(xué)技術(shù)一等獎（第一完成人）、中國化學(xué)會青年化學(xué)獎、中國化學(xué)會-英國皇家化學(xué)會青年化學(xué)獎、Biomaterials Science Lectureship等學(xué)術(shù)榮譽(yù)；承擔(dān)基金委創(chuàng)新研究群體等國家級重點(diǎn)科研項(xiàng)目；2015年起連續(xù)入選“全球高被引學(xué)者”（材料、化學(xué)）；任生物材料領(lǐng)域旗艦期刊Biomaterials雜志副主編和十余個國際主流期刊編委。2019年起積極推動自主研究成果的臨床應(yīng)用轉(zhuǎn)化，多個項(xiàng)目進(jìn)入臨床試驗(yàn)階段。

代表成果

[1] Jialu Xu, Yue Yu, Yue Zhang, Huaxing Dai, Qianyu Yang, Beilei Wang, Qingle Ma, Yitong Chen, Fang Xu, Xiaolin Shi, Zhuang Liu*, Chao Wang* “Oral administration of garlic-derived nanoparticles improves cancer immunotherapy by inducing intestinal IFNγ-producing γδ T cells” Nat. Nanotechnol., 19, 1569–1578 (2024)
[2] Chenya Wang, Liping Zhong, Jiachen Xu, Qi Zhuang, Fei Gong, Xiaojing Chen, Huiquan Tao, Cong Hu, Fuquan Huang, Nailin Yang, Junyan Li, Qi Zhao, Xinjun Sun, Yu Huo, Qian Chen, Yongxiang Zhao*, Rui Peng* , Zhuang Liu*.“Oncolytic mineralized bacteria as potent locally administered immunotherapeutics” Nat. Biomed. Eng., 8, 561-578 (2024)
[3] Wenjun Zhu, Ting Wei, Yuchun Xu, Qiutong Jin, Yu Chao, Jiaqi Lu, Jun Xu, Jiafei Zhu, Xiaoying Yan, Muchao Chen, Qian Chen *, Zhuang Liu*. “Non-invasive transdermal delivery of biomacromolecules with fluorocarbon-modified chitosan for melanoma immunotherapy and viral vaccines” Nat. Commun., 15, 820 (2024)
[4] Yu Chao, Zhuang Liu*, “Biomaterials tools to modulate the tumour microenvironment in immunotherapy”, Nat. Rev. Bioeng., 1, 125-138 (2023)
[5] Yuqing Li, Xueliang Liu, Lu Yu, Xin Huang, Xuan Wang, Da Han,* Yu Yang,* and Zhuang Liu*. “Covalent LYTAC Enabled by DNA Aptamers for Immune Checkpoint Degradation Therapy” J. Am. Chem. Soc., 145，45,24506-24521 (2023)
[6] Yujie Zhu, Zhijuan Yang, Zijian Pan, Yu Hao, Chunjie Wang, Ziliang Dong, Quguang Li, Yikai Han, Longlong Tian, Liangzhu Feng*, Zhuang Liu*. “Metallo-alginate hydrogel can potentiate microwave tumor ablation for synergistic cancer treatment” Sci. Adv., 8, 31, 5285 (2022)
[7] Han Zhang, Wenjun Zhu, Qiutong Jin, Feng Pan, Jiafei Zhu, Yanbin Liu, Linfu Chen, Jingjing Shen, Yang Yang*, Qian Chen*, and Zhuang Liu*. “Inhalable nanocatchers for SARS-CoV-2 inhibition” Proc. Natl. Acad. Sci. U.S.A., 118(29): e2102957118 (2021)
[8] Jun Xu, Jia Lv, Qi Zhuang, Zongjin Yang, Zhiqin Cao, Ligeng Xu, Pei Pei, Chenya Wang, Hanfei Wu, Ziliang Dong, Yu Chao, Chao Wang, Kai Yang, Rui Peng*, Yiyun Cheng* and Zhuang Liu*. A general strategy towards personalized nanovaccines based on fluoropolymers for post-surgical cancer immunotherapy” Nat. Nanotechnol., 15, 1043-1052 (2020)
[9] Yu Chao, Ligeng Xu, Chao Liang, Liangzhu Feng, Jun Xu, Ziliang Dong, Longlong Tian, Xuan Yi, Kai Yang* and Zhuang Liu*. "Combined Local Immunostimulatory Radioisotope Therapy and Systemic Immune Checkpoint Blockade Imparts Potent Antitumour Responses" Nat. Biomed. Eng., 2, 611-621(2018)
[10] Qian Chen, Ligeng Xu, ChaoLiang, Chao Wang, Rui Peng, Zhuang Liu*, "Photothermal therapy with immune-adjuvant nanoparticles together with checkpoint blockade for effective cancer immunotherapy" Nat. Commun., 7, 13193 (2016)

*以上信息由高級會員個人更新和維護(hù)。