劉磊

男， 清華大學化學系， 教授/研究員/教授級高工或同等級別

學習/工作經(jīng)歷

1999 年畢業(yè)于中國科學技術(shù)大學化學系，導師郭慶祥教授。
2004年在Columbia大學化學系獲得博士學位，導師Ronald Breslow教授。
2004-2007年在Scripps研究所從事博士后研究，導師Chi-Huey Wong教授。
2007年進入清華大學工作至今。

研究領(lǐng)域和興趣

蛋白質(zhì)化學合成

主要業(yè)績

發(fā)現(xiàn)蛋白酰肼反應，建立了蛋白質(zhì)化學合成新方法。使用蛋白酰肼方法，完成修飾組蛋白、多聚泛素、核酸聚合酶、細胞趨化因子等多種蛋白質(zhì)的化學合成，闡明生物化學及結(jié)構(gòu)機制，對生物活性及藥用蛋白進行化學合成與結(jié)構(gòu)改性研究，開展人工合成生命分子體系尤其是鏡像人工生命體系的探索。

代表成果

1. Ge-Min Fang, Yi-Ming Li, Fei Shen, Yi-Chao Huang, Jia-Bin Li, Yun Lin, Hong-Kui Cui, Lei Liu*. Protein chemical synthesis by ligation of peptide hydrazides. Angew. Chem. Int. Ed., 2011, 50, 7645-7649.

2. Ge-Min Fang, Jia-Xing Wang, Lei Liu*. Convergent chemical synthesis of proteins by ligation of peptide hydrazides. Angew. Chem. Int. Ed., 2012, 51, 10347-10350.

3. Yi-Chao Huang, Yi-Ming Li, Yang Chen, Man Pan, Yi-Tong Li, Li Yu, Qing-Xiang Guo, Lei Liu*. Synthesis of autophagosomal marker protein LC3-II under detergent-free conditions. Angew. Chem. Int. Ed., 2013, 52, 4858-4862.

4. Yi-Ming Li, Yi-Tong Li, Man Pan, Xiu-Qi Kong, Yi-Chao Huang, Zhang-Yong Hong, Lei Liu*. Irreversible site-specific hydrazinolysis of proteins by use of sortase. Angew. Chem. Int. Ed., 2014, 53, 2198-2202.

5. Shan Tang, Yan-Yan Si, Zhi-Peng Wang, Kun-Rong Mei, Xin Chen, Jing-Yuan Cheng, Ji-Shen Zheng, Lei Liu*. An efficient one-pot four-segment condensation method for protein chemical synthesis. Angew. Chem. Int. Ed., 2015, 54, 5713-5717.

6. Man Pan, Shuai Gao, Yong Zheng, Xiaodan Tan, Huan Lan, Xianglong Tan, Demeng Sun, Lining Lu, Tian Wang, Qingyun Zheng, Yichao Huang, Jiawei Wang, Lei Liu*. Quasi-racemic X-ray structures of K27-linked ubiquitin chains prepared by total chemical synthesis. J. Am. Chem. Soc., 2016, 138, 7429-7435.

7. Chao Zuo, Wei-Wei Shi, Xiao-Xu Chen, Marie Glatz, Bernd Riedl, Ingo Flamme, Elisabeth Pook, Jiawei Wang, Ge-Min Fang, Donald Bierer, Lei Liu*. Chimeric protein probes for C5a receptors through fusion of the anaphylatoxin C5a core region with a small-molecule antagonist. Sci. China Chem., 2019, 62, 1371-1378.

8. Lu-Jun Liang, Guo-Chao Chu, Qian Qu, Chong Zuo, Junxiong Mao, Qingyun Zheng, Jingnan Chen, Xianbin Meng, Yangwode Jing, Haiteng Deng, Yi-Ming Li, Lei Liu*. Chemical synthesis of activity-based E2-ubiquitin probes for the structural analysis of E3 ligase-catalyzed transthiolation. Angew. Chem. Int. Ed., 2021, 60, 17171-17177.

9. Man Pan*, Qingyun Zheng, Tian Wang, Lujun Liang, Junxiong Mao, Chong Zuo, Ruichao Ding, Huasong Ai, Yuan Xie, Dong Si, Yuanyuan Yu*, Lei Liu*, Minglei Zhao*. Structural insights into Ubr1-mediated N-degron polyubiquitination. Nature, 2021, 600, 334-338.

10. Huasong Ai, Maoshen Sun, Aijun Liu, Zixian Sun, Tingting Liu, Lin Cao, Lujun Liang, Qian Qu, Zichen Li, Zhiheng Deng, Zebin Tong, Guochao Chu, Xiaolin Tian, Haiteng Deng, Suwen Zhao, Jia-Bin Li*, Zhiyong Lou*, Lei Liu*. H2B Lys34 ubiquitination induces nucleosome distortion to stimulate Dot1L activity. Nat. Chem. Biol., 2022, 18, 972-980.

*以上信息由高級會員個人更新和維護。