巢暉

男， 中山大學(xué)化學(xué)學(xué)院， 教授/研究員/教授級高工或同等級別

學(xué)習(xí)/工作經(jīng)歷

學(xué)士（1988-1992）：湘潭師范學(xué)院（現(xiàn)湖南科技大學(xué)）化學(xué)系
碩士（1994-1997）：南開大學(xué)化學(xué)學(xué)院
博士（1997-2000）：中山大學(xué)化學(xué)與化學(xué)工程學(xué)院
訪問學(xué)者 (2000-2003)：香港科技大學(xué)化學(xué)系
博士后（2004-2005）：美國Texas A&M大學(xué)化學(xué)系
講師（2000-2002）：中山大學(xué)化學(xué)與化學(xué)工程學(xué)院
副教授（2002-2007）：中山大學(xué)化學(xué)與化學(xué)工程學(xué)院
教授（2007-2016）：中山大學(xué)化學(xué)與化學(xué)工程學(xué)院
教授（2016-至今）：中山大學(xué)化學(xué)學(xué)院

研究領(lǐng)域和興趣

化學(xué)生物學(xué)、無機(jī)化學(xué)

主要業(yè)績

國家杰出青年科學(xué)基金獲得者（2015），入選教育部“新世紀(jì)優(yōu)秀人才支持計(jì)劃”（2006）和廣東特支計(jì)劃“百千萬工程領(lǐng)軍人才”（2015）。主要從事基于金屬配合物的生物熒光探針和抗腫瘤藥物研究。作為主持人承擔(dān)國家自然科學(xué)基金、973計(jì)劃課題、教育部、廣東省科技項(xiàng)目等30多項(xiàng)。在《Chem. Soc. Rev》、《Coord. Chem. Rev》、《Nature Chemistry》、《Nat. Commun.》、《Proc. Natl, Acad. Sci. USA》、《Angew. Chem. Int. Ed.》、《Adv. Mater.》、《Biomaterials》等國際期刊發(fā)表第一作者或通訊作者SCI論文220多篇，論文被引用8000多次；申請中國發(fā)明專利17件，授權(quán)13件；參編專著、教材7部。2005年獲中國化學(xué)會“青年化學(xué)獎”， 2011年獲廣東省科學(xué)技術(shù)獎一等獎（第二完成人），2012年被評為南粵優(yōu)秀教師（廣東省），2012年獲國家自然科學(xué)獎二等獎（第三完成人），2014年獲寶鋼優(yōu)秀教師獎。目前擔(dān)任中國化學(xué)會化學(xué)生物學(xué)專業(yè)委員會委員、中國感光學(xué)會光化學(xué)與光生物專業(yè)委員會委員、廣東省化學(xué)會常務(wù)理事、廣東省化學(xué)會化學(xué)生物學(xué)專業(yè)委員會主任委員、藥物化學(xué)與分子診斷教育部重點(diǎn)實(shí)驗(yàn)室（河北大學(xué)）學(xué)術(shù)委員會委員、理論有機(jī)化學(xué)與功能分子教育部重點(diǎn)實(shí)驗(yàn)室（湖南科技大學(xué)）學(xué)術(shù)委員會副主任委員、《Scientific Reports》編委、《Journal of Inorganic Biochemistry》編委。

代表成果

1. Xueze Zhao,? Jiangping Liu? (?equal contributors), Jiangli Fan*, Hui Chao*, Xiaojun Peng, “Recent progress in photosensitizers for overcoming the challenges of photodynamic therapy: from molecular design to application”, Chem. Soc. Rev., 50 (2021) 4185-4219.
2. Leli Zeng, Pranav Gupta, Yanglu Chen, Enju Wang, Liangnian Ji, Hui Chao*, Zhe-Sheng Chen*, "The development of anticancer ruthenium(II) complexes: from single molecule compounds to nanomaterials", Chem. Soc. Rev., 46 (2017) 5771-5804. (Inside front cover)
3. Tao Feng, Johannes Karges, Xinxing Liao, Liangnian Ji, Hui Chao*, “Engineered Exosomes as a Natural Nanoplatform for Cancer Targeted Delivery of Metal-Based Drugs”, Coord. Chem. Rev., 454 (2022) 214325.
4. Jinchao Shen, Thomas W Rees, Liangnian Ji, Hui Chao*, “Recent advances in ruthenium(II) and iridium(III) complexes containing nanosystems for cancer treatment and bioimaging”, Coord. Chem. Rev., 443 (2021) 214016.
5. Fangmian Wei?, Thomas W. Rees? (?equal contributors), Xinxing Liao, Liangnian Ji, Hui Chao*, “Oxygen self-sufficient photodynamic therapy”, Coord. Chem. Rev., 432 (2021) 213714.
6. Kangqiang Qiu, Hongyi Zhu, Thomas W. Rees, Liangnian Ji, Qianling Zhang*, Hui Chao*, “Recent advances in lysosome-targeting luminescent transition metal complexes”, Coord. Chem. Rev., 398 (2019) 113010.
7. Kangqiang Qiu, Yu Chen, Thomas W. Rees, Liangnian Ji, Hui Chao*, “Organelle-targeting metal complexes: From molecular design to bio-applications”, Coord. Chem. Rev., 378 (2019) 66-86.
8. Jiangping Liu, Chen Zhang, Thomas W. Rees, Libing Ke, Liangnian Ji, Hui Chao?, “Harnessing ruthenium(II) as photodynamic agents: encouraging advances in cancer therapy”, Coord. Chem. Rev., 363 (2018) 17–28.
9. Yu Chen?, Ruilin Guan? (?equal contributors), Chen Zhang, Juanjuan Huang, Liangnian Ji, Hui Chao?, “Two-photon luminescent metal complexes for bioimaging and cancer phototherapy”, Coord. Chem. Rev., 310 (2016) 16-40.
10. Guanying Li, Ruilin Guan, Liangnian Ji, Hui Chao*, “DNA condensation induced by metal complexes”, Coord. Chem. Rev., 281 (2014) 100-113.
11. Yu Chen, Thomas W. Rees, Liangnian Ji, Hui Chao*, “Mitochondrial dynamics tracking with iridium(III) complexes”, Curr. Opin. Chem. Biol., 43 (2018) 51-57.
12. Huaiyi Huang?, Samya Banerjee? (?equal contributors), Kangqiang Qiu, Pingyu Zhang, Olivier Blacque, Thomas Malcomson, Martin J. Paterson, Guy J. Clarkson, Michael Staniforth, Vasilios G. Stavros, Gilles Gasser*, Hui Chao*, Peter J. Sadler*, “Targeted photoredox catalysis in cancer cells”, Nat. Chem., 11 (2019) 1041-1048.
13. Johannes Karges, Shi Kuang, Federica Maschietto, Olivier Blacque, Ilaria Ciofini, Hui Chao*, Gilles Gasser*, “Rationally Designed Ruthenium Complexes for 1- and 2-Photon Photodynamic Therapy”, Nat. Commun., 11 (2020) 3262.
14. Zhixuan Zhou?, Jiangping Liu? (?equal contributors), Juanjuan Huang, Thomas W. Rees, Heng Wang, Xiaopeng Li, Hui Chao*, Peter J. Stang*, “A self-assembled Ru-Pt metallacage as a lysosome-targeting photosensitizer for two-photon photodynamic therapy”, Proc. Natl, Acad. Sci. USA, 116 (2019) 20296-20302.
15. Zhixuan Zhou?, Jiangping Liu? (?equal contributors), Thomas W. Rees, Heng Wang, Xiaopeng Li, Hui Chao*, Peter J. Stang*, “A Heterometallic Ru-Pt Metallacycle for Two-Photon Photodynamic Therapy”, Proc. Natl, Acad. Sci. USA, 115 (2018) 5664-5669.
16. Shi Kuang?, Fangmian Wei? (?equal contributors), Johannes Karges, Libing Ke, Kai Xiong, Xinxing Liao, Gilles Gasser*, Liangnian Ji, Hui Chao*, “Photo-Decaging of A Mitochondria-Localized Iridium(III) Endoperoxide Complex for Two-Photon Photoactivated Therapy under Hypoxia”, J. Am. Chem. Soc., 144 (2022) 4091?4101.
17. Kai Xiong?, Cheng Ouyang? (?equal contributors), Jiaqi Liu, Johannes Karges, Xinlin Lin, Xiang Chen, Yu Chen*, Jian Wan*, Liangnian Ji, Hui Chao*, “Chiral RuII-PtII Complexes Inducing Telomere Dysfunction against Cisplatin-Resistant Cancer Cells”, Angew. Chem. Int. Ed., 61 (2022) e202204866.
18. Libing Ke?, Fangmian Wei? (?equal contributors), Lina Xie, Johannes Karges, Yu Chen, Liangnian Ji, Hui Chao*, “A Biodegradable Iridium(III) Coordination Polymer for Enhanced Two-Photon Photodynamic Therapy using an Apoptosis-Ferroptosis Hybrid Pathway”, Angew. Chem. Int. Ed., 61 (2022) e202205429. (Hot Paper)
19. Chengzhi Jin, Guanying Li, Xia Wu, Jiangpin Liu, Weijun Wu, Toshio Sasaki, Hui Chao*, Ye Zhang*, “Robust Packing of a Self-Assembling Iridium Complex via Endocytic Trafficking for Long-Term Lysosome Tracking”, Angew. Chem. Int. Ed., 60 (2021) 7597-7601.
20. Lili Wang, Ruilin Guan, Lina Xie, Xinxing Liao, Kai Xiong, Thomas W. Rees, Yu Chen, Liangnian Ji, Hui Chao*, “An ER-Targeting Iridium(III) Complex which Induces Immunogenic Cell Death in Non-Small Cell Lung Cancer”, Angew. Chem. Int. Ed., 60 (2021) 4657-4665. (VIP Article)
21. Cheng Ouyang, Yongguang Li, Thomas W. Rees, Xinxing Liao, Jianhua Jia, Yu Chen*, Xiting Zhang*, Liangnian Ji, Hui Chao*, “Supramolecular Assembly of An Organoplatinum(II) Complex with Ratiometric Dual Emission for Two-Photon Bioimaging”, Angew. Chem. Int. Ed., 60 (2021) 4150-4157.
22. Shi Kuang?, Lingli Sun? (?equal contributors), Xianrui Zhang, XinXing Liao, Thomas W. Rees, Leli Zeng, Yu Chen*, Xiting Zhang*, Liangnian Ji, Hui Chao*, “A Mitochondrion-Localized Two-Photon Photosensitizer Generating Carbon Radicals against Hypoxic Tumors”, Angew. Chem. Int. Ed., 59 (2020) 20697-20703.
23. Kai Xiong, Chen Qian, Yixian Yuan, Lin Wei, Xinxing Liao, Liting He, Thomas W. Rees, Yu Chen*, Jian Wan*, Liangnian Ji, Hui Chao*, “Necroptosis Induced by Ruthenium(II) Complexes as Dual Catalytic Inhibitors of Topoisomerase I/II”, Angew. Chem. Int. Ed., 59 (2020) 16631-16637. (Hot Paper)
24. Chengzhi Jin?, Fengyin Liang? (?equal contributors), Jinquan Wang, Lili Wang, Jiangping Liu, Xinxing Liao, Thomas W. Rees, Bo Yuan, Hui Wang, Yong Shen*, Zhong Pei*, Liangnian Ji, Hui Chao*, “Rational Design of Cyclometalated Iridium(III) Complexes for Three-Photon Phosphorescence Bioimaging”, Angew. Chem. Int. Ed., 59 (2020) 15987-15991. (Hot Paper)
25. Shi Kuang, Xinxing Liao, Xianrui Zhang, Thomas W. Rees, Ruilin Guan, Kai Xiong, Yu Chen*, Liangnian Ji, Hui Chao*, “FerriIridium: A Lysosome-Targeting Iridium(III) Prodrug for Iron(III)-Activated Chemotherapy in Gastric Cancer Cells”, Angew. Chem. Int. Ed., 59 (2020) 3315-3321. (VIP Article)
26. Johannes Karges, Uttara Basu, Olivier Blacque, Hui Chao*, Gilles Gasser*, “Polymeric encapsulation of novel homoleptic bis(dipyrrinato) zinc(II) complexes with long lifetimes for applications as photodynamic therapy photosensitisers”, Angew. Chem. Int Ed., 58 (2019) 14334-14340.
27. Pingyu Zhang?, Cookson K. C. Chiu? (?equal contributors), Huaiyi Huang, Yuko P. Y. Lam, Abraha Habtemariam, Thomas Malcomson, Martin J. Paterson, Guy J. Clarkson, Peter B. O’Connor*, Hui Chao*, Peter J. Sadler*, "Organo-iridium photosensitizers can induce specific oxidative attack on proteins in cancer cells", Angew. Chem. Int. Ed., 56 (2017) 14898-14902. (VIP Article, Inside front cover)
28. Huaiyi Huang?, Bole Yu? (?equal contributors), Pingyu Zhang, Juanjuan Huang, Yu Chen, Gilles Gasser*, Liangnian Ji, Hui Chao*, “Highly charged ruthenium(II) polypyridyl complexes as lysosome-localized photosensitizers for two-photon photodynamic therapy”, Angew. Chem. Int. Ed., 54 (2015) 14049-14052. (VIP Article)
29. Jia Li, Leli Zeng*, Zheng Wang, Hengxing Chen, Shuo Fang, Jinquan Wang, Chao-Yun Cai, Enming Xing, Xinxing Liao, Zhi-Wei Li, Charles R. Ashby Jr, Zhe-Sheng Chen*, Hui Chao*, Yihang Pan*, “Cycloruthenated Self-Assembly with Metabolic Inhibition to Efficiently Overcome Multidrug Resistance in Cancers”, Adv. Mater., 34 (2022) 2100245.
30. Fangmian Wei, Johannes Karges, Jinchao Shen, Lina Xie, Kai Xiong, Xiting Zhang*, Liangnian Ji, Hui Chao*, “A Mitochondria-Localized Oxygen Self-Sufficient Two-Photon Nano-Photosensitizer for Ferroptosis-Boosted Photodynamic Therapy under Hypoxia”, Nano Today, 44 (2022) 101509.

*以上信息由高級會員個人更新和維護(hù)。