戴偉民

男， 香港科技大學(xué)， 教授/研究員/教授級(jí)高工或同等級(jí)別

學(xué)習(xí)/工作經(jīng)歷

1978.10–1982.07，杭州大學(xué)化學(xué)系本科學(xué)生
1982.08–1984.12，中國(guó)科學(xué)院上海有機(jī)化學(xué)研究所碩士研究生
1985.01–1985.09，中國(guó)科學(xué)院上海有機(jī)化學(xué)研究所博士研究生
1985.10–1990.04，日本京都大學(xué)化學(xué)研究所博士研究生
1990.05–1992.08，美國(guó)Scripps研究所博士后研究員
1992.09–1997.12，香港科技大學(xué)化學(xué)系助理教授
1998.01–2007.06，香港科技大學(xué)化學(xué)系副教授
2007.07–2023.06，香港科技大學(xué)化學(xué)系教授
2023.07–, 香港科技大學(xué)化學(xué)系榮休教授及兼任教授

研究領(lǐng)域和興趣

不對(duì)稱催化和立體選擇反應(yīng)，具有生物醫(yī)藥意義分子的合成，海洋大環(huán)內(nèi)酯和其它復(fù)雜天然產(chǎn)物的全合成

主要業(yè)績(jī)

1. 建立了用烯丙基重排合成共軛烯二炔的獨(dú)特方法并用于烯二炔類抗癌劑前藥的設(shè)計(jì)和合成。
2. 開發(fā)了獨(dú)有的基于芳基甲酰胺骨架的Aphos系列磷氧半穩(wěn)定雙配位配體，用于室溫條件下的氯代芳烴和鹵代烯烴的Suzuki–Miyaura偶聯(lián)反應(yīng)，底物適用范圍廣，在大環(huán)內(nèi)酯類天然產(chǎn)物全合成中得到了應(yīng)用。其中含軸手性Aphos系列配體已應(yīng)用于不對(duì)稱烯丙基烷基化反應(yīng)、不對(duì)稱Heck反應(yīng)、及不對(duì)稱Suzuki–Miyaura偶聯(lián)反應(yīng)。
3. 開展了多樣性導(dǎo)向有機(jī)合成、微波輔助有機(jī)合成及組合化學(xué)等研究，建立了合成多種雜環(huán)的新方法，發(fā)展了微波輔助Ugi四組分反應(yīng)及后續(xù)環(huán)化反應(yīng)相結(jié)合的合成策略，用于雜環(huán)化合物的高效合成。
4. 建立了多模塊組裝（multimodule assembly）的合成策略，用于海洋大環(huán)內(nèi)酯類天然產(chǎn)物的多樣性全合成，已經(jīng)完成基于高級(jí)共同中間體的Amphidinolide T系列5個(gè)大環(huán)內(nèi)酯及其類似物的全合成和基于烯烴閉環(huán)復(fù)分解反應(yīng)的Amphidinolide X和Y、24-Demethylbafilomycins、Mycolactone E、Iriomoteolide-1a/-1b立體異構(gòu)體、Palmyrolide A、及Laingolides等的全合成。

代表成果

1. Wei-Min Dai,* Kin Chiu Fong, Hiroshi Danjo, and Sei-ichi Nishimoto, Synthesis of cis-Enediynes from 1,5-Diynes by Rearrangement of an Allylic Double Bond, Angew. Chem. Int. Ed. Engl. 1996, 35, 779–781. [DOI: 10.1002/anie.199607791]
2. Wei-Min Dai,* Kwong Wah Lai, Anxin Wu, Wataru Hamaguchi, Mavis Yuk Ha Lee, Ling Zhou, Atsushi Ishii, and Sei-ichi Nishimoto, DNA Cleavage Potency, Cytotoxicity, and Mechanism of Action of a Novel Class of Enediyne Prodrugs, J. Med. Chem. 2002, 45, 758–761. [DOI: 10.1021/jm015588e]
3. Wei-Min Dai,* Kelly Ka Yim Yeung, Jin-Ting Liu, Ye Zhang, and Ian D. Williams, A Novel Class of Nonbiaryl Atropisomeric P,O-Ligands for Palladium-Catalyzed Asymmetric Allylic Alkylation, Org. Lett. 2002, 4, 1615–1618. [DOI: 10.1021/ol0258233]
4. Wei-Min Dai,* Dian-Shun Guo, Li-Ping Sun, and Xiang-Hong Huang, Microwave-Assisted Solid-Phase Organic Synthesis (MASPOS) as a Key Step for an Indole Library Construction, Org. Lett. 2003, 5, 2919–2922. [DOI: 10.1021/ol0350543]
5. Li-Ping Sun and Wei-Min Dai*, An Engineered Linker Capable of Promoting On-Resin Reactions for Microwave-Assisted Solid-Phase Organic Synthesis, Angew. Chem. Int. Ed. 2006, 45, 7255–7258. [DOI: 10.1002/anie.200602523]
6. Jian Jin, Yile Chen, Yannian Li, Jinlong Wu, and Wei-Min Dai*, Total Synthesis of Amphidinolide Y by Formation of Trisubstituted (E)-Double Bond via Ring-Closing Metathesis of Densely Functionalized Alkenes, Org. Lett. 2007, 9, 2585-2588. [DOI: 10.1021/ol0710360]
7. Wei-Min Dai,* Yannian Li, Ye Zhang, Congyong Yue, and Jinlong Wu, Generation of an Aromatic Amide-Derived Phosphane (Aphos) Library by Self-Assisted Molecular Editing and Applications of Aphos in Room-Temperature Suzuki-Miyaura Reactions, Chem. Eur. J. 2008, 14, 5538–5554. [DOI: 10.1002/chem.200800318]
8. Huoming Li, Jinlong Wu, Jialu Luo, and Wei-Min Dai,* A Concise Total Synthesis of Amphidinolide T2, Chem. Eur. J. 2010, 16, 11530–11534. [DOI: 10.1002/chem.201001794]
9. Chengsen Cui and Wei-Min Dai,* Total Synthesis of Laingolide B Stereoisomers and Assignment of Absolute Configuration, Org. Lett. 2018, 20, 3358–3361. [DOI: 10.1021/acs.orglett.8b01269]
10. Jingjing Xu, Benguo Lin, Xiuqing Jiang, Zejun Jia, Jinlong Wu,* and Wei-Min Dai,* Intramolecular Diels?Alder Cycloaddition Approach toward the cis-Fused D5,6-Hexahydroisoindol-1-one Core of Cytochalasins, Org. Lett. 2019, 21, 830–834. [DOI: 10.1021/acs.orglett.8b04129]
11, Man Ki Sit, Hui Hui Cao, Yan-Dong Wu, Tsz Chun Yip, Lars Eric Bendel, Wen Zhang, and Wei-Min Dai,* Synthesis of the Macrolactone Cores of Maltepolides via a Diene–Ene Ring-Closing Metathesis Strategy, Org. Lett. 2023, 25, 1633–1637. [DOI: 10.1021/acs.orglett.3c00106]

*以上信息由高級(jí)會(huì)員個(gè)人更新和維護(hù)。